Amplitude estimation, in its original form, is formulated as phase estimation upon the Grover iterate. Subsequent improvements to the algorithm have eliminated the need for phase estimation and introduced low-depth variants that trade speedups for lower circuit depth. We make the key observation that amplitude estimation is equivalent to estimating the energy gap of an effective Hamiltonian, whereby discrete-time evolution is generated by amplitude amplification. This enables us to develop an amplitude estimation algorithm for both Heisenberg-limited and low-depth circuit regimes, inspired by statistical phase estimation techniques developed for early fault-tolerant ground-state energy estimation. In the Heisenberg-limited regime, our approach achieves performance comparable to state-of-the-art methods while using simplified classical post-processing. In the low-depth regime, it obtains optimal query–depth tradeoffs up to polylogarithmic factors, with provable guarantees and improved empirical performance over prior approaches. The resulting protocol is ancilla-free and requires only standard Grover reflections. Due to its flexibility, generality, and robustness, we expect our approach to be a key enabler for a broad range of early fault-tolerant applications.

We introduce quantum Kolmogorov-Arnold networks (QKAN), a quantum algorithmic framework inspired by the recently proposed Kolmogorov-Arnold Networks (KAN). QKAN inherits the compositional structure of KAN and is based on block-encodings, constructed recursively from a single layer using quantum singular value transformation. We demonstrate the algorithmic utility of QKAN in two applications. First, we introduce and analyze QKAN as a quantum learning model, treating the eigenvalues of block-encoded matrices as neurons and applying parametrized activation functions on the edges of the network. We show that QKAN is a wide-and-shallow neural architecture, where shallow depth is compensated by exponentially wide layers whenever efficient block-encodings of inputs are available. We further discuss how to parametrize and train QKAN using parametrized quantum circuits and quantum linear algebra subroutines. Second, we demonstrate that QKAN can serve as a multivariate quantum state-preparation protocol for functions with shallow compositional structure. We demonstrate this by efficiently preparing a multivariate Gaussian quantum state using a two-layer QKAN. Looking forward, we anticipate that QKAN’s compositional and modular design will enable new applications in quantum machine learning and quantum state preparation.

Fault-tolerant Quantum Processing Units (QPUs) promise to deliver exponential speed-ups in select computational tasks, yet their integration into modern deep learning pipelines remains unclear. In this work, we take a step towards bridging this gap by presenting the first fully-coherent quantum implementation of a multilayer neural network with non-linear activation functions. Our constructions mirror widely used deep learning architectures based on ResNet, and consist of residual blocks with multi-filter 2D convolutions, sigmoid activations, skip-connections, and layer normalizations. We analyse the complexity of inference for networks under three quantum data access regimes. Without any assumptions, we establish a quadratic speedup over classical methods for shallow bilinear-style networks. With efficient quantum access to the weights, we obtain a quartic speedup over classical methods. With efficient quantum access to both the inputs and the network weights, we prove that a network with an N-dimensional vectorized input, k residual block layers, and a final residual-linear-pooling layer can be implemented with an error of ε with O(polylog(N/ε)^k) inference cost.

Solving linear systems is of great importance in numerous fields. Proposed quantum algorithms for preparing solutions for linear systems include the HHL algorithm with subsequent refinements and variational methods. Circulant linear systems appear in many physics-related differential equations. An interesting case is banded circulant linear systems whose non-zero terms are within distance K of the main diagonal. For these systems, we propose an approach based on the classical combination of quantum states (CQS) method relying on convex optimization against the available analytical solution. From decompositions into cyclic permutations, the solution can be approximately represented by a classical combination of a polynomial number of quantum states. We validate our methods using classical simulations as well as execution on an IBM quantum computer. While in the setting of this paper, efficient classical algorithms are available, our results demonstrate the potential applicability of the CQS method for solving physics problems such as heat transfer.

Accurately computing the free energies of biological processes is a cornerstone of computer-aided drug design, but it is a daunting task. The need to sample vast conformational spaces and account for entropic contributions makes the estimation of binding free energies very expensive. While classical methods, such as thermodynamic integration and alchemical free energy calculations, have significantly contributed to reducing computational costs, they still face limitations in terms of efficiency and scalability. We tackle this through a quantum algorithm for the estimation of free energy differences by adapting the existing Liouvillian approach and introducing several key algorithmic improvements. We directly implement the Liouvillian operator and provide an efficient description of electronic forces acting on both nuclear and electronic particles on the quantum ground state potential energy surface. This leads to super-polynomial runtime scaling improvements in the precision of our Liouvillian simulation approach and quadratic improvements in the scaling with the number of particles relative to prior quantum algorithms. Second, our algorithm calculates free energy differences via a fully quantum implementation of thermodynamic integration and alchemy, thereby foregoing expensive entropy estimation subroutines used in prior works. Our results open new avenues towards the application of quantum computers in drug discovery.

Classical algorithms for market equilibrium computation such as proportional response dynamics face scalability issues with Internet-based applications such as auctions, recommender systems, and fair division, despite having an almost linear runtime in terms of the product of buyers and goods. In this work, we provide the first quantum algorithm for market equilibrium computation with sub-linear performance. Our algorithm provides a polynomial runtime speedup in terms of the product of the number of buyers and goods while reaching the same optimization objective value as the classical algorithm. Numerical simulations of a system with 16384 buyers and goods support our theoretical results that our quantum algorithm provides a significant speedup.

Classical learning of the expectation values of observables for quantum states is a natural variant of learning quantum states or channels. While learning-theoretic frameworks establish the sample complexity and the number of measurement shots per sample required for learning such statistical quantities, the interplay between these two variables has not been adequately quantified before. In this work, we take the probabilistic nature of quantum measurements into account in classical modelling and discuss these quantities under a single unified learning framework. We provide provable guarantees for learning parameterized quantum models that also quantify the asymmetrical effects and interplay of the two variables on the performance of learning algorithms. These results show that while increasing the sample size enhances the learning performance of classical machines, even with single-shot estimates, the improvements from increasing measurements become asymptotically trivial beyond a constant factor. We further apply our framework and theoretical guarantees to study the impact of measurement noise on the classical surrogation of parameterized quantum circuit models. Our work provides new tools to analyse the operational influence of finite measurement noise in the classical learning of quantum systems.

Hybrid quantum-classical computing in the noisy intermediate-scale quantum (NISQ) era with variational algorithms can exhibit barren plateau issues, causing difficult convergence of gradient-based optimization techniques. In this paper, we discuss post-variational strategies, which shift tunable parameters from the quantum computer to the classical computer, opting for ensemble strategies when optimizing quantum models. We discuss various strategies and design principles for constructing individual quantum circuits, where the resulting ensembles can be optimized with convex programming. Further, we discuss architectural designs of post-variational quantum neural networks and analyze the propagation of estimation errors throughout such neural networks. Finally, we show that empirically, post-variational quantum neural networks using our architectural designs can potentially provide better results than variational algorithms and performance comparable to that of two-layer neural networks.

Current neural network solutions in scientific document processing employ models pretrained on domain-specific corpi, which are usually limited in model size, as pretraining can be costly and limited by training resources. We introduce a framework that uses data augmentation from such domain-specific pretrained models to transfer domain specific knowledge to larger general pretrained models and improve performance on downstream tasks. Our method improves the performance of Named Entity Recognition in the astrophysical domain by more than 20% compared to domain-specific pretrained models finetuned to the target dataset.

Logical structure recovery in scientific articles associates text with a semantic section of the article. Although previous work has disregarded the surrounding context of a line, we model this important information by employing line-level attention on top of a transformer-based scientific document processing pipeline. With the addition of loss function engineering and data augmentation techniques with semi-supervised learning, our method improves classification performance by 10% compared to a recent state-of-the-art model. Our parsimonious, text-only method achieves a performance comparable to that of other works that use rich document features such as font and spatial position, using less data without sacrificing performance, resulting in a lightweight training pipeline.